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High Cholesterol Message Board


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I am currently taking 1,000mg Immediate release Niacin at bed time to help raise my HDL under my doctor’s approval and under his care. He approved of me taking 1,000mg Niacin a day and I am due to have another lipid panel done in February. I am slightly confused on what form of Niacin will be best to raise my HDL. My Doctor advised I can take either time released Niacin or immediate release. I tried slo-niacin 500mg twice a day for a week and had no issues. Now I am on 1,000mg immediate release Niacin one 1,000mg capsule at bed time. Just wanted to ask what would be best. Any comments or suggestions would be greatly appreciated.
From everything I've read the immediate release Niacin is the most effective and safest of the two. Since the immediate release is not harmful to the liver those who can tolerate it gradually work their way up to as much as 3000mg. I would guess that if your doing ok with the 1000mg in about a month the doctor might suggest going to 1500mg. The flush will most likely return but after a while your body will adjust and the flush will go away or weaken. The important thing to remember is if you miss a dose you should return to back to your original starting dose or the flush could be very severe. I've heard of this happening to people who just missed taking it for I day. I know a few people who take it and after they finally got comfortable with the flush they claim the kinda like it. They say its kinda weird but they like the way they feel afterward. Good luck and hope you see some good improvement in the HDL.
Immediate release Niacin is the benchmark for all other forms of niacin to compare to. The reason other forms of niacin were developed is that most can't take the flushing from immediate release Niacin.

If you are having luck taking immediate release Niacin, then you should not have any issue with your liver and should also get the best results. Try your best to achieve the 2000 mg dossage. You are one of the lucky few that can tollerate immediate release Niacin.
Arizona77, can you please tell me if it matters what brand of "immediate release" niacin you are taking? I have read in the past about the prescription "Niaspan" but I think that is something else. I was taking Inositol hexacosinate for awhile. Not sure which is which.
[QUOTE=The Mayor;3237767]Arizona77, can you please tell me if it matters what brand of "immediate release" niacin you are taking? I have read in the past about the prescription "Niaspan" but I think that is something else. I was taking Inositol hexacosinate for awhile. Not sure which is which.[/QUOTE]

Hi Mayor,

I take one twin labs 1,000mg capsule at bed time. Niaspan is time released Niacin available by prescription only. To my understanding Niacin in the from of Inositol hexacosinate, non-flush form, is not as effective as straight Nicotinic acid which is pure Niacin, Vitamin B3. My Doctor advised me to take twin labs 1,000mg pure
Nicotinic acid-Niacin with flush is best as opposed to non-flush Inositol hexacosinate. When I first started Niacin the flush was real hard to get threw for about two weeks but now I tolerate it very well. Also each brand of Niacin will be different as there is no 1:1 ratio with all brands. It is best when taking Niacin to stick with one brand and then you will know what will work best. Please be sure to check with your Doctor before starting any Niacin therapy . Hope this helps. :)
[QUOTE=The Mayor;3237767] I have read in the past about the prescription "Niaspan" but I think that is something else. [/QUOTE]

I can attest to how great Niaspan is and works. It cut my cholesterol numbers 50% and increased my HDL more than 25%. And the side effects are reduced greately compared to immediate release niacin. Niaspan is considered a extended release niacin and is designed to work without causing damage to your liver like Slo-Niacin can and does.

I should also say that any high dose of anything can hurt your liver... just that Slo-Niacin has a history of wrecking havic on folk's livers.

If you have insurance that pays for prescriptions... I'd blow by the immediate release niacin and try Niaspan... you will get was less side effects than the immediate release.

The best tip I can give is to take Niaspan only at bedtime (this is how it's prescribed)... and it's best if taken an hour or two since last eating.

Best of luck. :)
[QUOTE=VentureMan;3238469]I can attest to how great Niaspan is and works. It cust my cholesterol number 50% and increased my HDL more than 15%. And the side effects are reduced greately compared to immediate release niacin. Niaspan is considered a extended release niacin and is designed to work without causing damage to your liver like Slo-Niacin can and does.

I should also say that any high dose of anything can hurt your liver... just that Slo-Niacin has a history of wrecking havic on folk's livers.

If you have insurance that pays for prescriptions... I'd blow by the immediate release niacin and try Niaspan... you will get was less side effects than the immediate release.

The best tip I can give is to take Niaspan only at bedtime (this is how it's prescribed)... and it's best if taken an hour or two since last eating.

Best of luck. :)[/QUOTE]

Hi Ventureman,

I agree with you completely and know that Niaspan is an excellent option for those that do not want to take statins. I can not attest but what I have heard from many Niaspan has worked great them. I am happy I stopped slo-niacin. My Doctor said no way with
slo-niacin as you mentioned it can cause all sorts of problems with long time usage since the pharmacology is completely different than prescription Niaspan. My Doctor wants me to stick with the 1,000mg immediate release and see how it works for me before he makes any changes. :cool:
Arizona77;
When you first started taking the IR "Immediate release" niacin did you start out with say 250 mg. per day for one week and then bump it up progressively? I really want to try the IR first before I go to any prescription
version. Just afraid i won't eb able to tolerate it but I know from reading, that the IR niacin is the one for least amount of side effects to your liver.
[QUOTE=VentureMan;3240448][/QUOTE]


Yeah... a lot of folks who take that first 500 mg tab of immediate flush niacin without understanding its side effects swear it almost killed them... that niacin is extremely dangerous stuff and should be taken off the market... :D[/QUOTE]

Yes it’s true...people have taken 500mg immediate release and have called 911 and thought they were having a medical emergency. ;) In all seriousness so many people in the country try to Doctor them selves and that is not a good idea. I just hear of horror stories of people taking some over the counter supplements with out their Doctor’s approval and have has some serious problems. I always check with my Doctor before doing anything.
[QUOTE=VentureMan;3240695]I tell my Doctor every step I take... That's what I pay him for... his medical advice. I would never self medicate. I pay $12K a year for medical for myself and family... I'm going to take advantage of it... including taking a proven prescribed medication called Niaspan. Costs me $50 for a 90 day supply -- 270, 1000 MG tabs. Would cost me $270 to $500 on my own. And I'm sure it costs the insurance company half this... if not less.

I use to work for the #1 wholesaler of pharmacuticles... and we would get "alarms" when some drugs were sold for less than 500% to 1000% markup... and this is before the retail drug stores marked up the price as well...

yep folks... some of these drugs you are paying 1500% markup...[/QUOTE

Hey Ventureman,

Good gosh....1500% that is not good.
Yes I agree with you fully that anyone trying to teat high cholesterol should do it under a Doctor's care. I have been using 1,000mg immediate release niacin. I wanted to ask if you know how many points one can typically expect their HDL to be raised with 1,000mg immediate release Niacin after six months? My Doctor wants to see me back in Febuary for anther lipid panel. Right now my HDL is at 42 as of my test this past August. I will continue to work out and eat right and take Red Yeast Rice to keep my LDL under control. I have heard people taking 2,000mg immediate release Niacin daily and having their HDL increase by 20-25 points.
[QUOTE=VentureMan;3242195]What brand of red yeast rice do you take...?

What size does it come in (how many capsules)...?[/QUOTE]

Hey Ventureman,

I take Now Foods plain Red Yeast Rice extract. It comes in 1,200mg capsules in both 60 and 120 count. I take one in the AM and PM both with food. It has worked great! I highly recommend this brand and all of their dietary supplements are second to none.

Also I am just concerned my Doctor has me on is too high of a does of Niacin at 2,000mg immediate release once at bed time. My LDL is at 75 and Trig are at 87. My HDL is at 42 and my Doctor wants it back in the 50's or higher where I was a year ago. My Doctor also wants me to continue with Red Yeast Rice. Do you think 2,000mg Niacin with the Red Yeast Rice is too much? Also I do not want to over load my liver but as you advised and what I understand is that immediate release Niacin is not tuff on your liver like Slo-Niacin is.
Just wanted to give a quick up date. Under my doctor's approval and under his care I am currently taking 1,000mg immediate release Niacin at bed time. Also I am taking 1,200mg Red yeast Rice twice daily as well. My Doctor said it was fine for me to take both. I am due for a lipid panel in February and will give a full report. I am just concerned about over loading my liver with both Niacin and Red yeast Rice. My Doctor never mentioned me going to see him earlier for a liver function test. In the past I have never had any liver issues and or any elevations in my liver enzymes. I trust my Doctor fully and could not be in better hands but I am just concerned as I do not want to overload my liver with these supplements.





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