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High Cholesterol Message Board

High Cholesterol Board Index

Combination therapy of these 2 drugs is generally considered a no-no , with potential major complications , read below the info from the tricor warnings. This is a decision you must make if the risk is worth it or not . this combination is what killed people when Baycol was on the market . It says right in the warning that the risk "does not " outweigh the benefit .

1. 5. Concomitant therapy with TRICOR and HMG-CoA reductase inhibitors (such as lovastatin, pravastatin, and simvastatin): No data exists on this combined therapy. The association of the chemically and pharmacologically related similar compound gemfibrozil and MevacorŪ (lovastatin) has been associated with rhabdomyolysis markedly elevated creatine kinase (CK) levels and myoglobinuria, leading in a high proportion of cases to acute renal failure.

In virtually all patients who have had an unsatisfactory lipid response to either drug alone, any potential lipid benefit of combined therapy with HMG-CoA reductase inhibitors and TRICOR does not outweigh the risks of severe myopathy, rhabdomyolysis, and acute renal failure. The use of fibrates alone, including TRICOR, may occasionally be associated with myositis, myopathy, or rhabdomyolysis. Patients receiving TRICOR and complaining of muscle pain, tenderness, or weakness should have prompt medical evaluation for myopathy, including serum creatinine kinase level determination. If myopathy/myositis is suspected or diagnosed, TRICOR therapy should be stopped.

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