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High Cholesterol Message Board

High Cholesterol Board Index

Yes that is what I was asking, there is something called Familial hypercholesterolemia, I just found a site that has info about it...


A dominantly inherited genetic condition that results in markedly elevated LDL (low-density lipoprotein) cholesterol levels beginning at birth, and resulting in myocardial infarctions (heart attacks) at an early age.
Causes, incidence, and risk factors Return to top

Affected people have consistently high levels of low-density lipoprotein, which leads to premature atherosclerosis of the coronary arteries. Typically in affected men, acute myocardial infarctions (heart attacks) occur in their 40s to 50s, and 85% of men with this disorder have experienced a heart attack by age 60. The incidence of heart attacks in women with this disorder is also increased, but delayed 10 years later than in men.

Individuals from families with a strong history of early heart attacks should be evaluated with a lipid screen. Proper diet, exercise, and the use of newer drugs can bring lipids down to safer levels.

It is possible for a person to inherit two genes for this disorder. This magnifies the severity of the condition. Cholesterol values may exceed 600 mg/cc. Affected individuals develop waxy plaques (xanthomas) beneath the skin over their elbows, knees, buttocks. These are deposits of cholesterol in the skin. In addition they develop deposits in tendons and around the cornea of the eye. Atherosclerosis begins before puberty and heart attacks and death may occur before age 30. Little of therapeutic value is presently available for this condition.

The incidence of familial hypercholesterolemia is 7 out of 1000 people.


a strong family history of familial hypercholesterolemia or early myocardial infarction
elevated and therapy-resistant levels of LDL in either or both parents
xanthomas (lesions caused by cholesterol rich lipoprotein deposits)
cholesterol deposits in the eyelids (xanthelasmas)
chest pain (angina) associated with coronary artery disease
evidence of obesity

WOW I know that I don't have that, my cholesterol isn't that severe. Here is also some other stuff I have found...

Familial combined hyperlipidemia (FCHL) affects an estimated 1 in 10 Americans with premature heart disease. FCHL results from defects in the metabolism of lipoproteins that leads to high cholesterol, high triglycerides or both. FCHL has been studied for 30 years, but many aspects of it remain a mystery. New research finds people with FCHL overproduce a substance called apolipoprotein (apoB). This substance is a component of cholesterol-containing particles made by the liver.

Researchers studied participants with FCHL and without FCHL. The investigators measured total cholesterol, triglycerides, apoB, abdominal fat and insulin resistance in all participants. Researchers found that the FCHL participants had significantly higher levels of total cholesterol, triglycerides, very-low and low-density lipoproteins, and apoB compared with the other participants.

Researchers say their study has made them shift their investigation into looking for the gene or genes responsible for the increases in apoB. They hope that in turn could lead to new treatments aimed at reducing heart disease. In the meantime, researchers say weight loss, a low-fat diet, regular exercise, as well as cholesterol lowering drugs if necessary are important for people with FCHL.

This study was reported in the April 12 issue of Arteriosclerosis, Thrombosis and Vascular Biology: Journal of the American Heart Association .

Though that would be interesting :D :D :D :D

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