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High Cholesterol Message Board


High Cholesterol Board Index


Hereis some info I found on the net about Niaspan that may be of some use to some people here ,certainly looks interesting to me if this can help people without oo many side effects .
Niaspan® is one of only two products in the United States approved for increasing HDL
levels. Low HDL cholesterol levels have been shown to be of the highest risk factors
contributing to coronary heart disease(CHD) and other dangerous cardiac conditions.
Possible causes of low HDL cholesterol include:
Obesity
Low total, high polyunsaturated fat diet
Cigarette smoking
Thiazide diuretics
Some beta-blockers
Probucol
Anabolic steroids
Liver or kidney failure
Hyperthyroidism
Some forms of diabetes
Acute inflammation/injury/stress
Genetic defects in proteins which influence serum HDL concentrations.
Most drugs for treating cholesterol problems are designed to reduce LDL ("bad
cholesterol") levels.Niaspan's active ingredient, niacin, on the other hand, is
most effective in elevating HDL ("good cholesterol") levels. This increase in HDL
has been shown to significantly reduce chances of CHD.

Niaspan's Once-At-Night™ dosing minimizes side effects, such as flushing and
liver enzyme elevations, associated with older niacin preparations.
In addition to increasing HDL cholesterol, Niaspan also lowers LDL cholesterol,
triglycerides, and lipoprotein.

Clinical Results

In clinical studies, Niaspan increased HDL levels by 14% to 32%. (at doses of
1,000 mg to 2,000 mg per day). Furthermore, a seven-year study published in
"The New England Journal of Medicine," indicated that a mere 6% increase in
HDL cholesterol yielded greater than 20% reductions in cardiac events and
stroke among 2,500 CHD patients whose only lipid abnormality at baseline was
low HDL cholesterol.
Side Effects

The most common side effect of Niaspan is flushing, which is characterized by redness, tingling, or itching that typically occurs on the face, neck, chest, and back. In most cases, the flushing sensation lasts for one hour, approximately two to four hours after taking the dose. To minimize flushing, avoid drinking alcohol or hot drinks close to taking the dose, and avoid taking Niaspan with spicy foods. Other less frequent side effects include upset stomach and rash.





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