It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....

Hepatitis Message Board

Hepatitis Board Index
Board Index > Hepatitis | 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

[QUOTE=smallercheeks]My dh was going to start on entecavir, haven't even received it from our HBO pharmacy yet, but reading all the nasty side effects, he is thinking now of doing the interferon instead. If he is going to be sick, may as well kill the darn virus instead of just lowering it. We live in a rural mountain part of Northern Calif., no support groups of any kind, have to drive over 2 hrs to a special doctor. Bummer. Unsure what to really do now.[/QUOTE]

Hi smaller,

Your hubby has hep b if they are recommending entecavir. and they will probably be recomending it in combination with lamuvidine--at least that's the combination that shows the highest percentage response in most studies. Yes, sometimes the response is 'permanent,' whatever that means. Interferon is also sometimes used for hep b, but the results are even less encouraging than the 50/50 results for hep c. Usually ifn produces sustained responses in only about a third or fewer of hep b patients treated. The advantage, however, is that if response is achieved it is very likely to be permanent, whereas the other tx's are less certain of this.
Interferon has also sometimes been used in combination with lamuvidine, and this combo shows higher probablility of clearing the virus than either medicine alone. (It also produces more side effects, at least in some people, see below.)

As you've probably read here or elsewhere, ifn, even the modern pegylated interferons (pegasys and peg-intron) have a host of very serious side effects (for some, or perhaps most, who take it), and some of these can be permanent in the unluckiest cases. so, the decision is not a light one. I would bet, from my limited readings, that acefovir (entecavir) is less debilitating for most people than is interferon.

the nice (??!!) thing about hep b, though, is that your husband and you have a range of choices, and if one therapy creates too serious a reaction, there are a few alternatives to choose from--pick another and try again. hep c folks are not so situated, at least not yet.

hep b is also somewhat more likely to resolve on its own than is hep c (I had hep b as well as c, and the b went away untreated. not so the c.)

It is worth doing your own research, of course, but it may be that your docs are suggesting the therapy of choice for you guys, and you would only go to ifn or other tx's if this does not work out.

let us know what you find out and work out.

and, best of luck!


All times are GMT -7. The time now is 05:36 PM.

© 2022 MH Sub I, LLC dba Internet Brands. All rights reserved.
Do not copy or redistribute in any form!