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Hello, I just received some blood work back from my rheumatologist and neurologist. For the first time in 10 years, I have a positive ANA. The results are POSITIVE, 1:80, homogeneous. I have seronegative enteropathic arthritis, uveitis, ulcerative colitis, and recently an abnormal neurological exam. What are the chances of this result meaning I have Lupus? I am on tons of arthritis medications (pred, humira, methotrexate...) but still suffer from joint and connective tissue pain that has me in a wheelchair and using crutches. Lyme titers and western blot are normal and WBC is high at 11.4. Any advice would be appreciated. :)
Wallis, hi! Have you read the "sticky posts" (permanent info posts) at the top of the thread list? The one about "test results" contains info on finding out about *more specific* tests that are typically run if ANA is high (like anti-ds-DNA, anti-Sm, anti-Ro, anti-La, anti-RNP, rheumatoid factor, etc.) Because ANA is only a threshold test and is positive in a number of conditions, further tests are typically done.

Another "sticky post" contains the ACR criteria for systemic lupus (SLE). To support the Dx, you generally must meet at least 4, over your lifetime, not necessarily all at once. Plus there are variant forms, sometimes called subsets, for which you may meet less than 4.

In Dr. Wallace's harcover lupus book, available in most libraries & bookstores, he writes that 1 to 4 percent of people with SLE also have UC, so it's clearly possible to have both.

Do you take aspirin/sulfa antibiotic combinations for your UC? Dr. Wallace makes the point that many lupus patients can't tolerate some sulfa derivatives. Certain of those sufla drugs are associated with a form of lupus called DILE = drug-induced lupus. DILE generally resolves when the offending drug is withdrawn. And in people with classic lupus (SLE), certain of those sulfa drugs are thought to cause flares.

If you want to read up on lupus, Dr. Wallace is a great source; and so is Dr. Robert Lahita (another rheumie/author). Hope there's something here that helps some. Bye for now, with my best wishes, Vee

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