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Shauna, I'm not a doctor (to put it mildly!). But Plaquenil could help someone ANA-negative for a few reasons that I've read about. First, maybe you do have positive ANA & positive autoantibodies, but all your bloodwork was done when those levels had fallen. Then there's that rare kind of SLE called Ro-lupus. Also, in the discoid lupus "subset", people remain ANA-negative. Finally, there are OTHER connective tissue diseases that can cause symptoms very similar to lupus.

Yes, there ARE quite a few lupus rashes one may not have read about---maybe as many as 15, which ticked me off when I finally read it! When my local GP first suspected lupus, I found only TWO lupus rashes discussed = malar and discoid. Because neither was anything like my rash, I concluded I couldn't possibly have lupus. WRONG! I finally took myself to the library and found descriptions of more lupus rashes; and since then, I've read about even more. (Who knew?!?)

So that's why I described the two forms of SCLE rashes, to illustrate how some of the older lupus literature failed to describe the range of rashes possible in lupus. But no one, not even a doctor, can always tell what rashes are, without doing a skin biopsy. And if lupus is a possibility, immunofluorescent stain tests can really prove the point, as they very often light up in weird lines that are considered "diagnostic" of ONLY lupus.

Are you avoiding sun? Have your rashes abated any since starting Plaquenil? If YES to both, I'd think that adds more weight to your rash being related to lupus, or to some other "close cousin". BUT if your rashes have *worsened* since starting Plaquenil, you'd really want to report that FAST. I think a small percent of people on Plaquenil get skin reactions & MUST stop taking it. Hope you post more soon. Meanwhile, sending my very best! Vee

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