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Re: Ana titer
Mar 2, 2012
pinklove1, hi & welcome. I'm just a patient, so please read in that light! I *think* that ANA reading is considered low because, of the two formats I've seen for ANA, it's likely the "ratio" format (as opposed to International Units = IU). If so, 1:40 would be the lowest positive that typically registers. Higher readings would progress as follows:
1:80, 1:160, 1:320, 1:640, 1:1280, and 1:2560.

The format reflects the test approach, which is to dilute the sample with some special solution that fluoresces, with the result being the last dilution at which any fluorescence is still visible... or something along those lines!

To provide some context: One well-known author of a lupus book written for patients states that 1:1280 is the level at which he becomes pretty darned sure that something is going on.

While ANA is almost always subtantially positive in systemic lupus, I know of two forms possible without a positive ANA. One is "discoid lupus" (DLE), which features scarring/depigmenting lesions and lperhaps some contitutional problems (mild fatigue), but is viewed as "skin-only". The other is a rare subset of systemic lupus called "Ro-lupus", in which anti-Ro is positive but ANA remains negative; however, the two SCLE rashes most associated with this subset don't really resemble petechaie.

Another thought: I have a ot of cutaneous vasculitis = little red dots, esp. on my ankles, but they're permanent, not transient.

Do you have any other symptoms? Are you on any meds that might be culprits? Anyway, I hope something above helps a little, that others chip in soon, and that you post again soon. Sending best wishes, sincerely, Vee

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