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Re: Test results
Jul 30, 2012
Anti-smooth muscle antibodies (anti-SMA) were previously
tested for by indirect immunofluorescence (IF) using
rat stomach as antigen. The smooth muscle in these
sections contains numerous proteins, including;
microfilaments (which contain F-actin), intermediate
filaments, and microtubules. Of these proteins, F-actin
has the closest association with autoimmune hepatitis
type 1 (AIH 1). To enhance our testing specificity for
AIH type 1, immunofluorescence has been replaced by an
ELISA based assay to purified F-actin. IgG antibodies
to F-actin are present in approximately 75% of patients
with AIH type 1, approximately 65% of patients with
autoimmune cholangitis, approximately 30% of patients
with primary biliary cirrhosis (PBS), and approximately
2% of healthy controls. High values are closely
correlated with AIH type 1.
DNA AB (DS) (CRITHIDIA)
C3, SERUM
C4, SERUM
THYROID PEROXIDASE AB
STRIATED MUSCLE AB
MYOCARDIAL AB, IF
GASTRIC PARIETAL CELL AB
NEGATIVE
101
24
<10
NEGATIVE
NEGATIVE
<20.0
< or = 20.0
20.1-24.9 Equivocal
> or = 25 Positive
NEGATIVE
ADULTS:90-180 mg/dL
ADULTS: 16-47 mg/dL
LESS THAN 35 IU/mL
NEGATIVE
NEGATIVE
U
Anti-gastric parietal cell antibodies (anti-GPA) were
CLIENT SERVICES: 800.669.6605 COLLECTED: 01/16/2012 15:22 CST
Quest, Quest Diagnostics, the associated logo and all associated Quest Diagnostics marks are the trademarks of Quest Diagnostics.
Negative
BRADY, MOLLY
DOB: 07/29/1977 AGE: 34
Gender: F
Phone: 504.912.6961 Patient ID: 15012
Health ID: 8573006423225249
Specimen: Requisition: Lab Ref #:
Collected: Received: Reported:
HU225868Y 0029842 SCRIPT
01/16/2012 / 15:22 CST 01/16/2012 / 22:59 CST 01/26/2012 / 12:44 CST
(* A Copy From)

Client #: 5555500
BERIOS, ANGELIS
DIRECT TO PATIENT - HOUSTON 5850 ROGERDALE RD HOUSTON, TX 77072-1602
Test Name
LUPUS (SLE) PANEL
ANA SCREEN, IFA
ANA, IFA PATTERN
ANA, IFA TITER
<1:40
1:40-1:80
>1:80
In Range
HOMOGENEOUS
Negative
Low Antibody Level
Elevated Antibody Level
Out Of Range
POSITIVE
1:40 H
Reference Range
NEGATIVE
titer
<14 IU/mL
<1.0 NEGATIVE AI
<1.0 NEGATIVE AI
<1.0 NEGATIVE AI
<1.0 NEGATIVE AI
<1.0 NEG AI
<1.0 NEGATIVE AI
NEGATIVE
NEGATIVE
U
RHEUMATOID FACTOR
SJOGREN'S ANTIBODIES(SSA)
SJOGREN'S ANTIBODIES(SSB)
SM ANTIBODY
SM/RNP ANTIBODY
SCL-70 ANTIBODY
RIBOSOMAL P PROTEIN AB
RETICULIN AB IGA
MITOCHONDRIAL AB
ACTIN ANTIBODY (IGG)
<20 Negative
20-30 Weak Positive
>30 High Positive
6
<1.0 NEG
<1.0 NEG
<1.0 NEG
<1.0 NEG
<1.0 NEG
<1.0 NEG
NEGATIVE
NEGATIVE
<20

Test Name In Range Out Of Range Reference Range Lab previously tested for by indirect immunofluorescence
(IF) using mouse stomach as a substrate. Identification
of the specific antibody target as H+/K+ ATPase protein
(a gastric proton pump) has led to the development of
an ELISA based assay. Antibodies to this protein are
present in approximately 80% of patients with
pernicious anemia and a small percentage of the general
adult population. The latter percentage increases with
age and may reflect the presence of atrophic gastritis.
A negative test does not exclude a diagnosis of
pernicious anemia. A test for intrinsic factor blocking
antibody (IFAB) may provide serological evidence in
support of the diagnosis in some of these patients.
TEST NOT PERFORMED:
RETICULIN AB IGA TITER
MITOCHONDRIAL AB TITER
DNA AB (DS) CRITH,TITER
STRIATED MUSCLE AB TITER
MYOCARDIAL AB TITER
Endnote 1
See Endnote 1
This test was developed and its performance
characteristics determined by Quest Diagnostics,
Nichols Institute. It has not been cleared or
approved by the U.S. Food and Drug Administration.
The FDA has determined that such clearance or
approval is not necessary. Performance
characteristics refer to the analytical
performance of the test.
*************************************
* TEST NOT PERFORMED *
* SCREENING TEST NEGATIVE. *
* TITER NOT PERFORMED. *
*************************************
Re: Test results
Jul 30, 2012
Anti-smooth muscle antibodies (anti-SMA) were previously
tested for by indirect immunofluorescence (IF) using
rat stomach as antigen. The smooth muscle in these
sections contains numerous proteins, including;
microfilaments (which contain F-actin), intermediate
filaments, and microtubules. Of these proteins, F-actin
has the closest association with autoimmune hepatitis
type 1 (AIH 1). To enhance our testing specificity for
AIH type 1, immunofluorescence has been replaced by an
ELISA based assay to purified F-actin. IgG antibodies
to F-actin are present in approximately 75% of patients
with AIH type 1, approximately 65% of patients with
autoimmune cholangitis, approximately 30% of patients
with primary biliary cirrhosis (PBS), and approximately
2% of healthy controls. High values are closely
correlated with AIH type 1.
DNA AB (DS) (CRITHIDIA)
C3, SERUM
C4, SERUM
THYROID PEROXIDASE AB
STRIATED MUSCLE AB
MYOCARDIAL AB, IF
GASTRIC PARIETAL CELL AB
NEGATIVE
101
24
<10
NEGATIVE
NEGATIVE
<20.0
< or = 20.0
20.1-24.9 Equivocal
> or = 25 Positive
NEGATIVE
ADULTS:90-180 mg/dL
ADULTS: 16-47 mg/dL
LESS THAN 35 IU/mL
NEGATIVE
NEGATIVE
U
Anti-gastric parietal cell antibodies (anti-GPA) were
CLIENT SERVICES: 800.669.6605 COLLECTED: 01/16/2012 15:22 CST
Quest, Quest Diagnostics, the associated logo and all associated Quest Diagnostics marks are the trademarks of Quest Diagnostics.
Negative
BRADY, MOLLY
DOB: 07/29/1977 AGE: 34
Gender: F
Phone: 504.912.6961 Patient ID: 15012
Health ID: 8573006423225249
Specimen: Requisition: Lab Ref #:
Collected: Received: Reported:
HU225868Y 0029842 SCRIPT
01/16/2012 / 15:22 CST 01/16/2012 / 22:59 CST 01/26/2012 / 12:44 CST
(* A Copy From)

Client #: 5555500
BERIOS, ANGELIS
DIRECT TO PATIENT - HOUSTON 5850 ROGERDALE RD HOUSTON, TX 77072-1602
Test Name
LUPUS (SLE) PANEL
ANA SCREEN, IFA
ANA, IFA PATTERN
ANA, IFA TITER
<1:40
1:40-1:80
>1:80
In Range
HOMOGENEOUS
Negative
Low Antibody Level
Elevated Antibody Level
Out Of Range
POSITIVE
1:40 H
Reference Range
NEGATIVE
titer
<14 IU/mL
<1.0 NEGATIVE AI
<1.0 NEGATIVE AI
<1.0 NEGATIVE AI
<1.0 NEGATIVE AI
<1.0 NEG AI
<1.0 NEGATIVE AI
NEGATIVE
NEGATIVE
U
RHEUMATOID FACTOR
SJOGREN'S ANTIBODIES(SSA)
SJOGREN'S ANTIBODIES(SSB)
SM ANTIBODY
SM/RNP ANTIBODY
SCL-70 ANTIBODY
RIBOSOMAL P PROTEIN AB
RETICULIN AB IGA
MITOCHONDRIAL AB
ACTIN ANTIBODY (IGG)
<20 Negative
20-30 Weak Positive
>30 High Positive
6
<1.0 NEG
<1.0 NEG
<1.0 NEG
<1.0 NEG
<1.0 NEG
<1.0 NEG
NEGATIVE
NEGATIVE
<20

Test Name In Range Out Of Range Reference Range Lab previously tested for by indirect immunofluorescence
(IF) using mouse stomach as a substrate. Identification
of the specific antibody target as H+/K+ ATPase protein
(a gastric proton pump) has led to the development of
an ELISA based assay. Antibodies to this protein are
present in approximately 80% of patients with
pernicious anemia and a small percentage of the general
adult population. The latter percentage increases with
age and may reflect the presence of atrophic gastritis.
A negative test does not exclude a diagnosis of
pernicious anemia. A test for intrinsic factor blocking
antibody (IFAB) may provide serological evidence in
support of the diagnosis in some of these patients.
TEST NOT PERFORMED:
RETICULIN AB IGA TITER
MITOCHONDRIAL AB TITER
DNA AB (DS) CRITH,TITER
STRIATED MUSCLE AB TITER
MYOCARDIAL AB TITER
Endnote 1
See Endnote 1
This test was developed and its performance
characteristics determined by Quest Diagnostics,
Nichols Institute. It has not been cleared or
approved by the U.S. Food and Drug Administration.
The FDA has determined that such clearance or
approval is not necessary. Performance
characteristics refer to the analytical
performance of the test.
*************************************
* TEST NOT PERFORMED *
* SCREENING TEST NEGATIVE. *
* TITER NOT PERFORMED. *
*************************************





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