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Lyme Disease Message Board

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Hey Sherlock,

You make me laugh! :D

I had a date last night so I wasn't on the computer. But I did find information that was listed in the "sticky threads" on this site (so don't give me any credit):

Earle, I listed your bands below (I wanted to explain the difference between IgM and IgG).

IgM antibodies are the first antibodies to be produced in the body in response to an infection, and is produced in great quantity. IgM antibodies are large, up to six times larger than the IgG antibodies. IgM antibodies, when present in high numbers, represent a new active infection or an existing infection that has become reactivated.

Over time, the number of IgM antibodies will decline as the active infection is resolved.

IgG antibodies are produced once an infection has been going on for a while, and may be present after the infection has been resolved. Generally speaking, the presence of IgG antibodies to an organism when accompanied by a negative IgM test for the same organism means that the person was exposed to that organism at one time and developed antibodies to it, but does not have a current active infection of that organism.

When it comes to Borrelia burgdorferi (Bb), the organism responsible for Lyme disease, that is not necessarily the case.

To recap, depending on the numbers,

IgM is a sign of a current infection.

IgG is a sign of a current infection, or of a past exposure to or past infection by the organism.

IgG considered positive if at least IGenex: 2 @ bands present
IgM considered positive if at least IGenex: 2 @ bands present

- - - - - - - - - - - - - - -
Okay Earle, these are your bands that you gave us:

41: Flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia

23-25: Outer surface protein C (OspC), specific for Bb

31: Outer surface protein A (OspA), specific for Bb

39 is a major protein of Bb flagellin; specific for Bb

Band IgG IgM
Band Definition

Bb: Borrelia burgdorferi
Bmp: Bacterial membrane protein
Fla: Flagellin
HGE: Human granulocytic ehrlichiosis
kDa: kilodalton = molecular weight
Oms: Outer membrane-spanning
Osp: Outer surface proteins
p: Protein

Band Markings:

When reporting bands, the reporting laboratory marks each band with the following indicators of intensity:

- Not present
+ Low
++ Medium
+++ High
+/- Equivocal = indeterminate (there, but not as intense as Low)

So my conclusion is that you tested Positive for Lyme because of Band 39 and Band 41 (even though you have one Plus Sign next to those bands). Personally, I do not agree with your doctor as doctors should also diagnose a person based on symptoms besides the bands.

Earle, what symptoms do you have at the moment?

When I first became infected with Lyme, I still continued to work for over 2 years full time and overtime, clean, cook, run around. As time went on, I only got worse until I couldn't do those things anymore.

Hope that helps,

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