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Re: IgeneX tests
Mar 25, 2006
Hi All:

Prema- You are right about those results for the IgM, but there is more to the story...

I had been looking this over very closely when I got my sons results so this is fresh in my mind. The IgM is actually very important in lyme since that is what shows current infection. In Lyme the IgG show past, but possibly resolved infection. This is opposite for things like allergies. The CDC has much more stict criteria than Igenex. Also, many of these band are lyme specific like 23-25, 31, 34, 39-so you would think if you had a positive on any of those it would be a diagnosis on its own. Apparently the CDC's criteria used to be less stringent, but they have back pedaled recently so instead of making progress with diagnosing lyme we are going backwards. :confused:

Actually the CDC has more strict criteria than Igenex. For the [B]IgM[/B] Igenex considers it positive if you have [B]2 or more[/B] of the following bands present:

23-25
31
34
39
41

The CDC considers the [B]IgM[/B] positive if you have [B]2 of the following 3 bands [/B] positive:

23-25
39
41

For an [B]IgG[/B] Igenex considers it positive if you have [B]2 or more of these bands[/B] present:

23-26
31
34
39
41
93
Igenex considers the [B]IgG[/B] equivocal if you have one of these bands present by itself with the exception of band 41 since it can be found in all spirochetes.

The CDC criteria for [B]IgG[/B] is:
that [B]5 of the following bands must be present[/B]
18
23-25
28
30
39
41
45
58
66
93

CDC considers it negative if less than five of any of these bands are positive.
The CDC also disregards bands 31 and 34 since they were used to make the vaccine that has been pulled off the market, even if you have not been vaccinated they will not count those bands if you react to them.

Frango
Re: IgeneX tests
Mar 25, 2006
Hi Prema and Frango,

I would comment further then I usually do :rolleyes: but I am having a bad day today with bad cramps from my period. Uggggggg!

Anyway, below are thoughts written by a well-known LLMD:

There are nine known Borrelia burgdorferi genus specie specific KDA Western Blot antibodies (bands): 18 23 30 31 34 37 39 83 and 93.

Only one of these Borrelia burgdorferi genus specie specific bands is needed to confirm that there is serological evidence of exposure to the Borrelia burgdorferi spirochete and can confirm a clinical diagnosis of Lyme disease.

[B]CDC[/B] Western Blot IgM surveillance criteria includes only two Borrelia burgdorferi genus specie specific antibodies for IgM 23 and 39 and excludes the other seven Borrelia burgdorferi genus specie specific antibodies.

[B]CDC[/B] Western Blot IgG surveillance criteria includes 18 23 30 37 39 and 93 and excludes bands 31 34 and 83.

It does not make sense to exclude any Borrelia burgdorferi genus specie specific antibodies in a Lyme Western Blot IgG and to include only two of these antibodies in IgM because all the antibodies in IgG were once IgM.

[I]IgM converts to IgG in about two months unless there is a persisting infection driving a persisting IgM reaction.[/I]

This is the case with any infection including the Borrelia burgdorferi induced Lyme disease.

[B]CDC wrongfully [/B] includes five non-specific cross-reacting antibodies in its Western Blot surveillance criteria: 28 41 45 58 and 66.

This leads to the possibility of false positive Lyme Western Blots.

There can be no false positives if only Borrelia burgdorferi genus specie specific antibodies are considered. One can have a CDC surveillance positive IgG Lyme Western Blot with the five non-specific antibodies without having any Borrelia burgdorferi genus specie specific antibodies.

[B]This does not make sense. [/B]

CDC recommends that the Lyme Western Blot be performed only if there is a positive or equivocal Lyme ELISA. In my practice of over 7000 children with Lyme disease, 30% with a CDC positive Lyme Western Blot have negative ELISA’s.

The Lyme ELISA is a poor screening test. An adequate screening test should have false positives not false negatives.





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