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Hi everyone,

Hi sure would appreciate any help you can give to help me better understand my test results. The Western Blot IGG was positive & the IGM was Indeterminate. But, I don't really understand what exactly the individual bands mean.
Do I really have Lyme? Part of the confusion is why my LLMD dr. hasn't treated me yet. These results are from 1.5 years ago and I haven't been treated yet. Is it possible the LLMD doesn't really think I have Lyme? (If he did, wouldn't he treat me--he says my allergies to pain meds make him think I will get an allergy to the antibiotics and then I will have to stop treatment and be worse off than before.) Should I seek out another LLMD????

Below I typed out the test results from my Western Blot (Igenex). Is the IGG a current infection? Is the IGM a past infection? Anything else I should know?

(The test says IND=Indeterminate; 1+ to 4+ is a positive with 4+being the strongest positive. If two or more doube starred bands are positive, the test is positive for Lyme. )

Western Blot IGG Positive
18 kDa +
22 kDa -
**23-25 kDa -
28 kDa -
30 kDa ++
**31 kDa IND
**34 kDa IND
37 kDa -
**39 kDa ++
**41 kDa++
45 kDa IND
58 kDa +
66 kDa IND
73 kDa -
83 kDa -
**93 kDa IND

Western Blot IgM Indeterminate
18 kDa ++
22 kDa -
**23-25 kDa -
28 kDa ++
30 kDa IND
**31 kDa++
**34 kDa -
37 kDa -
**30 kDa -
**41 kDa IND
45 kDa -
58 kDa IND
66 kDa +
73 kDa -
83 kDa -
93 kDa IND

Also, the Epstein Barr Virus IGG was very, very high with 6.28 (positive is 1.10 or greater)

Mycoplasma Pneumoniae Ab IGG was very high with 3.20 (positive is 1.10 or greater)

Cytomegalovirus IGG is high with 1.58 (positive is 1.10 or higher)

Thanks for your help!!!
Kayda
Hi kayda. Below is the Western Blot band description:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia (sometimes people with Lyme who have
this band positive also have the co-infection Ehrlichiosis)
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

The IgM tests for a more resent infection, the IgG a longer standing one. Band 41 is often the first to show and yours is positive. Bands 31, 34, and 39 are Lyme specific and yours are IND or positive. These results are significant.

You have had this for a year and a half and the doctor will not treat you? Why? Have you been tested for all the co-infections? Did you know that Mycoplasma is one of the co-infections?

You need to see a knowledgeable doctor. If you need a recommendation, let us know.
Kayda

Who told you that a CD57 of 11 was good? It is better than 0, but it is not good. Normal is between 60 - 360.

The CD57 test is quite specific for Lyme disease, meaning that if it is below range and you are having symptoms that reflect Lyme then there is a great chance that you have Chronic Lyme disease. If you do a search for CD57 and then look at the first article you find then that should give you some good scientific based info.

IgM usually means current or recent infection. IgG usually means past infection. However for Lyme disease it is not so clear cut. You say you also have Mycoplasma P.

Both of these should be treated with Antibiotics. You say that you have an LLMD and he hasnt given you any antibiotics after 1.5 years of symptoms. Doesnt seem right to me. i think you need a new LLMD. Lyme disease is a clinical diagnosis anyway, even though you have results to prove it.

EBV and CMV can lead to complications especially in immuno suppressed patients. However if you tested many people without symptoms there would be many that tested positive. I doubt they are as significant as your Lyme and Mycoplasma infections.

Good luck, but if I was you I would definetley be looking for a 2nd opinion!
Steve
Hi Steve,

Thanks for your post. I will try to answer your questions:

>Who told you that a CD57 of 11 was good? It is better than 0, but it is not good. Normal is between 60 - 360.

My LLMD dr. told me 11 was very good. I am looking at the test results and see that 11 is "In Range" however there is no "Reference Range." :confused: I also had a Lymphocyte subset panel 1 which shows T Cells, Helper cells, Suppressor T Cells, NKC, B Cells & Lyphocytes to be in range. There are "Reference Ranges" for each of these.


>>The CD57 test is quite specific for Lyme disease, meaning that if it is below range and you are having symptoms that reflect Lyme then there is a great chance that you have Chronic Lyme disease. If you do a search for CD57 and then look at the first article you find then that should give you some good scientific based info.<<

I will do the search and see what I come up with. I had no idea that the CD57 was specific for Lyme. Thanks for the explanation of the test. :) I think this LLMD knows the right tests to order, but I am confused about the non-treatment. :confused: He just says with my allergies to pain meds, he thinks I will develop allergies to antibiotics, will have to stop and then I will be worse off than before I started treatment. The last thing I want is to be worse off. :dizzy:

>>IgM usually means current or recent infection. IgG usually means past infection. However for Lyme disease it is not so clear cut. You say you also have Mycoplasma P<<

So, is it possible IGG could be current? If IGG is past infection, does it mean my body has dealt with it already and it is not infecting me now? Yes, it is true I am positive for M. Pneumoniae AB, IGG my result: 3.20 (1.10 or greater is positive). (M.Pneumoniae AB IGM was negative.)

>>Both of these should be treated with Antibiotics. You say that you have an LLMD and he hasnt given you any antibiotics after 1.5 years of symptoms. Doesnt seem right to me. i think you need a new LLMD. Lyme disease is a clinical diagnosis anyway, even though you have results to prove it.<<

This doesn't seem right to me either. That's why I wondered if I truly have Lyme. :confused: Although, I must say the LLMD was starting to speak about a treatment plan until I told him about my drug allergies & sensitivies to pain medicine. Then he stopped & switched course. I wonder if the Lyme caused my drug allergies. (they have gotten bad in the last two years. Before that, I didn't have problems taking pain meds.) Do you know if it could?

>>EBV and CMV can lead to complications especially in immuno suppressed patients. However if you tested many people without symptoms there would be many that tested positive. I doubt they are as significant as your Lyme and Mycoplasma infections.<<

So, I should concentrate on the Lyme and the Mycoplasma. Can EBV be re-activated?? I wonder if that is why I am so fatigued (inaddition to the Lyme)

>>Good luck, but if I was you I would definetley be looking for a 2nd opinion!<<
Isn't it ironic that here I have a Positive test for Lyme & Mycoplasma and I am not getting treated. :dizzy: Many here struggle to get tested, some never do and yet they do get treatment. I do not really know of any other LLMD's. I am going to call an alternative medicine clinic which I just heard of. They do not use antibiotics. All of this is SO hard to do when you're so sick:dizzy: . It must be done, though.

Do you think Lyme and Mycoplasma can be beat without antibioitics? Will Salt/C or Dr. J's tinctures do it? Antibiotics (for my heart and sinus infections have messed up my stomach/digestive symptoms horribly).

Thanks Steve. I'm sorry this got so long. Looks more like a book!
Kayda
Hi Ticker,

Thanks! I wrote the name down of the dr. in PA. Any names for the Hyde Park or Armonk locations? Sorry if I'm being dumb here. Can I get it by searching Lyme & the city names?

My Western Blot Test IGM & IGG & FISH were done at Igenex.
Mycoplasma, Epstein Barr, Lymphocyte, CD-57, Thyroid, CMV was done at Quest.

Should I get a CD-57 done again at Igenex?

Do you think it's possible to beat Lyme without antibiotics or is that the million dollar question.??

Kayda





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