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Lyme Disease Message Board


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Hi Diane, welcome to the board!

Are you currently taking Mepron and Clindamycin or are you also doing the IV meds?

It is my understanding that Mepron needs to be prescribed with Zithromax, Biaxin, or Ketek to be effective. It is used to treat Babesiosis, a co-infection which is similar to malaria.

How long were you sick before getting diagnosed? It is normal to feel worse before feeling better, and it can take time. Are you seeing a Lyme doctor? Two months of treatment is not long at all. Were you tested for the other co-infections also: Ehrlihciosis (HME & HGE), Bartonellla, and Mycoplamsa? This is important. Many Lyme doctors believe the co-infections need to be treated first. Having them can complicate treatment and progress.

Are you aware of the Jarisch-Herxheimer Reaction (herx)? Often, when people who have Lyme take antibiotics, their symptoms become worse or they get new ones. When the antibiotics kill the bacteria, toxins are released making them feel sicker. It can be very scary when it happens, but it is a good sign the antibiotics are working. Although it can vary individually, many people experience this at the beginning of treatment and every three to four weeks.

It is a good idea to document your symptoms daily. One way to do this is to list the three main symptoms you have each day and a numerical rating of their severity, from 1-10. Over time when you review this, you can see when your herxes occur and how you are responding to the meds.

Hang in there okay?
Hi Diane. I don't know which doctor you are seeing, but I have never heard of a knowledgeable doctor saying the herx happens only once. It happens throughout treatment. Over time as the bacteria load decreases, the herxes should become less intense.

You need to be tested for the other co-infections also by a Lyme lab such as IgeneX. Which lab did your Western Blot? If you have Lyme specific bands that are positive, you have Lyme disease.

Which doctor are you going to get a second opinion from?

Babesiosis is similar to malaria and needs to be treated with a combination of an anti-malarial and antibiotic. Often this is Mepron (anti-malarial) with Zithromax, Biaxin, or Ketek (antibiotic). I believe that in the past, Quinine was combined with Clindamycin. I believe that the Mepron combo is supposed to be more effective and have fewer side effects. I would talk with your doctor about this. I have never heard of taking Clindamycin with Mepron.

It is very important to learn as much as possible. I recommend reading Dr. Joseph Burrascano's 2005 Diagnostic Hints and Treatment Guidelines For Lyme and Other Tick Borne Illnesses. He also discusses the co-infections and necessary treatment. He is one of the top Lyme doctors in the country, and many Lyme doctors follow his protocols. I also recommend the book "Everything You Need To Know About Lyme Disease (2nd edition)" by Karen Vanderhoof-Forschner.





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