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Ticker,
Got a copy of the labs

Lyme Disease IGG and IGM,
Western Blot
B. Burgdorferi AB
(IGG), WB Negative
18 KD (IGG) Band Non Reactive
23 KD (IGG) Band Non Reactive
28 KD (IGG) Band Non Reactive
30 KD (IGG) Band Non Reactive
39 KD (IGG) Band Non Reactive
41 KD (IGG) Band Reactive
45 KD (IGG) Band Non Reactive
58 KD (IGG) Band Non Reactive
66 KD (IGG) Band Non Reactive
93 KD (IGG) Band Non Reactive

IGG western blots which have 5 or more of the 10 significant bands are considered positive for specific antibody to b. burgdorferi.(proceedings of the 2nd conf. on lyme disease, Dearborn, MI, 1994.)


B.Burgdorferi AB
(IGM) WB Negative
23 KD (IGM) Band Non Reactive
39 KD (IGM) Band Non Reactive
41 KD (IGM) Band Non Reactive

IGM western blots which have 2 or more of the 3 significant bands are considered positive for specific antibody to b. burgdorferi. (proceedings of the 2nd conf. on lyme disease, Dearborn, MI 1994)

I hope you can make sense of this . It seems like the guidelines of this test were from 1994 ?? She also had a epstein barr virus panel that was negative.
Mycoplasma was positive and thyroid was elevated-

Thank You for taking the time to help.
Hi serinity. The IgM tests for a more recent infection, the IgG a longer standing infection. Below is the breakdown of the Western Blot bands:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia (sometimes people with Lyme who have
this band positive also have the co-infection Ehrlichiosis)
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

Band 41 is often the first to show. The CDC requires a large number of bands to show for the test to be considered positive; however, many people who have Lyme disease do not get this many bands. It is important to be tested by a Lyme lab such as IgeneX in Palo Alto, CA. They use more sensitive tests and list more bands on the Western Blot--including Lyme specific bands 31 and 34 which I do not see listed here.

Although only about 50% of people who have Lyme ever get a rash, a bulls-eye rash is a definite sign of Lyme. The rash alone merits treatment. I highly recommend that you have both of your children evaluated by a Lyme knowledgeable doctor. The sooner they get properly treated, the better. Getting proper treatment early in the infection may reduce the chance of long-term complications.

I know this is a lot to digest. Learn as much as you can, and keep asking questions. Knowledge is power. The good news is that good help is available, and you are not alone. Hang in there okay?





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