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[QUOTE=SouthCarolina07;2989264]I know the CDC says I don't have Lyme... But what are your thoughts? How significant are these test reults? Thanks in advance...

BTW, I realize I totally butchered the spelling of "decipher". I swear I know how to spell, I just typed it without thinking. lol.


18kDa. -
22 -
**23-25 -
28 -
30 -
**31 -
**34 -
**39 IND
**41 +
45 -
58 -
66 +
73 -
**83-93 -


18kDa. -
22 -
**23-25 +
28 +
30 -
**31 ++++
**34 IND
**39 IND
**41 ++
45 -
58 +
66 -
73 -
**83-93 -[/QUOTE]

Don't worry about the spelling, I have Lyme type dyslexia, I know how to spell, but my right hand moves faster than my left so I type the letters backwards, Who had the Igenex tests run for you? As I see it you have Chronic Late-stage LD, I'm saying that just by looking at your Igenex IGG Western Blot, What led you to get tested for LD? How long have you had the symptoms of LD? The Igenex pos. is a real good indicator, and the CDC has set it's guidelines merely for reporting purposes, LLMD's don't go by the CDC protocal for daig. Lyme anyway. You have the Lyme specific bands very positve, and significant bands (double starred) pos. and IND too. Yours is actually the first one i have seen that has so many +'s. the IGM antibodies are the first to show up in early infection, then the IGG antibodies kick in and take over for the IGM, you can still have IGM antibodies active at the same time as IGG, but the amount of IGG antibodies that your body is creating and the lack of the IGM antibodies is a sure sign of late-stage LD. Have you had a CD57 run? What about co-infections? I don't know of an LLMD in SC, but I'm sure someone on the board does, Sarah:wave:
Hi SouthCarolina07, welcome to the board!

Below is the breakdown of the Western Blot bands:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia (sometimes people with Lyme who have
this band positive also have the co-infection Ehrlichiosis)
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

The IgM tests for a more recent infection, the IgG a longer standing one. Band 41 is often the first to show, and yours is positive. Bands 23-25, 31, 34, and 39 are Lyme specific bands and yours are either positive or IND.

The CDC requires a large number of bands to show for it to be considered positive, yet many people who have Lyme do not have this many bands show. Lyme doctors often focus on which bands show, some are specific for Lyme. Your results are signifcant.

How long have you been sick? Are you being treated? Are you seeing a Lyme doctor? it is very important to see a knowledgeable doctor. Many doctors do not understand Lyme and treat with outdated protocols. No test is completely reliable, and results can vary by lab. Lyme needs continuous, aggressive treatment. Besides Lyme, ticks can also transmit several co-infections including Babesiosis, two types of Ehrlichiosis (HME & HGE), Bartonella, and Mycoplasma. It is estimated that 60% of people who have Lyme are co-infected. It may affect treatment choice and progress. It is important to be tested for these by a Lyme reputable lab such as IgeneX in Palo Alto, CA.

If you need a doctor recommendation, let us know.

It is also important to learn as much as possible. I recommend reading Dr. Joseph Burrascano's 2005 Diagnostic Hints and Treatment Guidelines For Lyme and Other Tick Borne Illnesses. He is one of the top Lyme doctors in the country, and many Lyme doctors follow his protocols. I also recommend the book "Everything You Need To Know About Lyme Disease (2nd edition)" by Karen Vanderhoof-Forschner.

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