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Lyme Disease Message Board


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I recently tested positive for bands 18, 30, 31, 34, 41, 45, 58, and 66 on the IgM WB, while the IgG WB was largely negative, except for IND at 41. From everything I've read, IgM response is first, followed by IgG in chronic Lyme. I have been experiencing symptoms for over a decade, and my doctor is skeptical about my having chronic Lyme. He thinks that I either have been recently exposed to Lyme, or all the positive bands are results of false positives - cross reactivity with non-Lyme antigens. Does anyone else here with chronic Lyme have only IgM positive WB? Any input is appreciated - I'm confused. By the way, I've never been vaccinated for Lyme.
So far I'm not on tx, and haven't been tested for coinfections. When my doctor (a resident at a family practice) suggested testing for EBV, ANA, and syphillis to rule out a false positive, I made a suggestion: rather than running all those tests (which would be expensive), why not find out which bands are cross-reactive with which antigens? For instance, if only the 28 KDa band is cross-reactive with say, EBV, but I tested negative for the 28 KDa band, then we could rule out EBV cross-reactivity, right? Upon my suggestion he referred me to an Infectious Diseases doc. I have a feeling I'm just going to get the run around because I'm don't officially have Lyme by CDC standards.
Just wanted to add that I also repeatedly have positive IgM and negative IgG test results -- 2 years after my initial lyme diagnosis. (And I definitely had lyme at that point 2 years ago -- bulls eye rash, fever, etc.)





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