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Lyme Disease Message Board


Lyme Disease Board Index


Hi Divermon. The ticker name is for tick-borne illnesses :)

Below is the breakdown of the Western Blot bands:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia (sometimes people with Lyme who have
this band positive also have the co-infection Ehrlichiosis)
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

The IgM tests for a more recent infection, the IgG a longer standing one. The CDC requires several bands to show for the test to be positive; however, many people who have Lyme do not have this many bands. Lyme doctors often look at which bands are positive. Some are specific for Lyme. Band 41 is often the first to show. Bands 23-25, 31, 34, and 39 are Lyme specific bands. You have several IND Lyme bands which is supposedly not positive but not negative. I think this is significant with your symptoms. Do you have the result for the IgG also?

Unfortunately, there are not many Lyme knowledgeable doctors in the country. There are none in TN. Definitely do not go to Vanderbilt! The closest one I know of is Dr. Charles Crist in Springfield, MO. I do not know if he treats aggressively enough. There was an excellent one in NC, but I have heard he is moving to DC next month. There are others in NY, CT, and CA who come highly recommended. If you would like other names, let me know.

Yes you are right that it is important to learn as much as you can, just like with thyroid issues. Knowledge is power. Although Lyme disease is the second fastest growing infectious disease in the US after AIDS and the number one vector-borne illness in the US, little is being done to educate people and the medical community.

I hope you can see a knowledgeable doctor soon.





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