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[COLOR="SeaGreen"]BigStan, below I have copied and pasted your post from the Open forum so we could respond here. [/COLOR]

Hi Everyone, I just received my test results faxed to me by my doctors office. I haven't met with him yet to go over the results. I'm trying to determine if I have Lyme but the IgeneX test data is complicated. Can anyone help me (Ticker), in dertermining if I really do have Lyme disease. What does anyone think positive or negative?? The results are:

Lyme IgM Western Blot, Lyme IgG Western Blot

18 kDa - 18 kDa -
22 kDa - 22 kDa -
**23-25 kDa - **23-25 kDa -
28 kDa - 28 kDa -
30 kDa - 30 kDa -
**31 kDa - **31 kDa IND
**34 kDa - **34 kDa -
**39 kDa - **39 kDa IND
**41 kDa - **41 kDa +++
45 kDa - 45 kDa +
58 kDa - 58 kDa +
66 kDa + 66 kDa +
73 kDa - 73 kDa -
**83-93 kDa - **83-93 kDa -



TEST RESULT

IFA. B Burgdorferi G/M/A <1:40 TITER

Interpretation Of Antibody Titers:
<1:40 Negative
1:40 Indeterminate
= OR > 1:80 Positive

TEST RESULT

Multiplex B. Burgdorferi (PCR)

GENOMIC OR PLASMID BURG Negative
PLASMID B BURGDORFERI Negative



Ticker, If you respond I just want to say hello and thank you for all the help and education on Lyme.
Hi BigStan. I am happy to help!

I am glad you were tested through IgeneX. The tests can be confusing.
Below is the breakdown of the Western Blot bands:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia (sometimes people with Lyme who have this band positive also have the co-infection Ehrlichiosis)
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

Band 41 is often the first to show in a Lyme infection, and yours is positive. The bands with the *** are Lyme specific bands, and yours are negative. Sometimes people who have band 45 postive are positive for the Ehrlichiosis co-infections. This was true in my case.

You really should be evaluated by a Lyme knowledgable doctor. Technically your Western Blot is negative, but many people who have Lyme have a negative Western Blot. The CDC requires several bands to show for it to be positive. Many people who have Lyme do not have this many bands present. Lyme doctors often look at which bands show. You have symptoms and band 41 is present.

The PCR is a DNA test for Lyme, and it looks like yours is negative.

I hope you can see a knowlegeable doctor soon.





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