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I will try to keep my post short and sweet, even though it is a long story! I am a married mother of two (10, 4) and I'm 31 years old. With over a decade of symptoms and visiting many different doctors, I finally received a diagnosis of fibromyalgia. (MS was ruled out through an MRI and by a neurologist) No doctor ever mentionedthe possibility of Lyme, but here are some of the symptoms I have have been dealing with over the years:

fatigue
anxiety and panic
depression
muscle pain (tender points and more)
cracking, popping joints
sore hips
painful foot bones
poor coordination
raynaud's (soles of feet)
irritable bladder/interstitial cystitis
reflux
dry/bloodshot eyes
motion sickness
heart palpitations, skipping beats
sensitivity to light, odors
irritable bowels
many visual problems - episodes of nystagmus, blurred vision, drooping eyelids
excessively mixing up letters while writing
poor concentration and memory
some weakness in arms and legs
swollen neck nodes all the time
headaches
episode of facial numbness

I am sure I left things out. Most of these, if not all, can be attributed to fibromyalgia. Recently, I realized though, that these symptoms followed a penny sized sore on the inside of my foot below my ankle over a decade ago. It wasn't a typical bullseye rash, but at the time I was very afraid of what it was. It took quite awhile to go away, but soon afterwards I became ill with flu-like symptoms and was taken to the hospital and was told I had a "virus."

I finally recently had a Western Blot and was told I tested negative for Lyme, but was found to have a low white blood count. I was not feeling well at all when I had my blood taken, so I am pretty sure my counts would be related to fighting a virus and hopefully not something too serious.

On my Lyme test, I tested positive on igg/igc bands 18, 23, and 66. On the igm I tested positive on band 39.

- do you think it is likely I am positive?
- could lead to a low white blood count?
- could still have lyme and had two healthy pregnancies AND a normal MRI?
- could the rash/sore I recall be related to lyme?
- What should my next step be since I did not meet CDC criteria? Should I test at Igenex or just "demand" my primary doc to treat me?

THANK YOU!
JP
Hi JP. No Lyme test is completely reliable.

Which lab did your Western Blot?

Below is the breakdown of the Western Blot bands:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia (sometimes people with Lyme who have
this band positive also have the co-infection Ehrlichiosis)
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

The IgM tests for a more recent infection, the IgG a longer standing one.

The CDC requires a large number of bands to show for it to be considered positive yet many people who have Lyme do not have this many bands show. Lyme doctors often focus on which bands show, some are specific for Lyme. It is important to be tested by a Lyme reputable lab such as IgeneX in Palo Alto, CA. They have more sensitive tests and list more bands on the Western Blot. Testing should be used as an aid in diagnosis not solely for diagnosis. A lyme knowledgeable doctor will not rely solely on test results to diagnose tick-borne illnesses.

Bands 23-25 and 39 are Lyme specific bands. I think your results combined with your symptoms are significant. I highly recommend that you see a Lyme doctor.





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