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Lyme Disease Message Board

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Hi Lymesgal, Let me explain it further. There are antibiotics that can't cross the brain barrier to kill Lyme. Most of the oral antibiotics. Although I hear that massive doses of Amoxicillin will do it. My LLMD said that's about the only oral that will. Once Lyme gets into the neurological system, you usually need to be put on an antibiotic that crosses the brain barrier. Most are antibiotics in the IV form. Here is a list of antibiotics that cross the BBB orals and IV. Not all of these are used to treat Lyme:

OFLOXACIN (racemic mixture) a fluoroquinolone

RIFAMPIN lipophilic ----------------- (all rifamycins)

METRONIDAZOLE (Flagyl)- lipophilic [used against Bb cysts]

COTRIMOXAZOLE (Bactrim) a sulfa drug -- (all

SPARFLOXACIN (Zagam) a fluoroquinolone

Ketek —from what I’ve read, crosses the BBB only weakly. Macrolide family, 4th generation,

LEVOFLOXACIN (L isomer of Ofloxacin) a fluoroquinolone

DOXYCYCLINE (vibramycin) a tetracycline type-lipophilic.

MINOCYCLINE-a Tetracycline


AMOXICILLIN- a penicillin type, passes BBB only weakly

Bicillin — a penicillin, passes bbb only weakly if at all; there’s some disagreement among pharacologists about this.

BIAXIN-a macrolide-passes BBB weakly

ZITHROMAX- a macrlide-passes BBB weakly

ERYTHROMYCIN a macrolide---passes BBB, but not as well as other antibiotics.

Tinidazole (Tindamax)— a 2005 drug ref says: Tinidazole is distributed into virtually all tissues and body fluids and also crosses the blood-brain barrier. [used against Bb cysts]


Generation III cephalosporins

I am currently on IV Rocephin (Ceftriaxone) which is a cephalosporin, 4 grams daily. I have not been on any other antibiotic to fight Lyme yet. Although my LLMD already told me he is going to try different meds to confuse the bacteria. He is going to put me on a cyst buster like Flagyl in addition to the Rocephin.

It is very possible there may be more cures or remissions when a "cyst buster" is added to rocephin. It would make sense. This has just recently become common treatment. So will see. I'm knew to this but have learned a lot. I am only 5 weeks into my picc line. I have know idea at this time how long I will have to have it. I had a very strong herx reaction in the past week which actually made me head to the ER once again.

Please ask your doctor to consider putting you on a picc and IV antibiotics. If you have been sick for seven years that's longer then myself and I would think that IV antibiotics would be the way to go. I'm not a doctor so there may be a reason your doctor hasn't done this. You said that you are seeing an LLMD which is good. They are more aggressive in treatment then regular MD's.

Let me know how it goes.:)

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