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Lyme Disease Message Board

Lyme Disease Board Index

Hi Rachelle. What other bands do you have?

The Western Blot IgM tests for a more recent infection and the IgG a longer standing one. I believe the * stands for Lyme specific bands. Band 31 is a Lyme specific band. I believe the the number of + indicate degree of being positive, but I am not sure. You could call IgeneX to see.
Hi Rachelle. Below is the breakdown of the Western Blot:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

The IgG tests for a longer standing infection. IgeneX uses more sensitive testing and list more bands on the Western Blot. Bands 23-25 and 31 are Lyme specific bands and yours are positive. Band 41 is often the first to show and yours is IND. I am not a doctor, but I think your results are significant and merit treatment.
Thanks Ticker...I just found a web article from the Bay Area Lupus Foundation and it says" Both lupus and Lyme disease can produce arthritis, skin rash, cardiac & neuro involvement. Occasionally patients with high titer antibodies can have a false-positive lyme antibody titer? go figure? My ANA titer has been the highest ever since falling ill also. Im just praying for a miracle at this point..thanks for your help. WIll see what this other doc has to say..thanks again for your time...Rachelle

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