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Hi Everyone,

My doc just emailed my IGeneX lab results and we have a phone in appt. tomorrow AM to go over them and discuss treatment protocol. It is somewhat confusing to me, but does appear I am IGeneX positive on the Western Blot IgM, but not CDC positive, which I'm sure will be an "out" for my insurance. I have 75% of the Lyme symptoms - I've been very sick for 2 years (though I believe infection was in Summer 2004) - most symptoms are neurological in nature. Anyway, to many of you experienced souls...if you have any information and input for me, it would be GREATLY appreciated!

WB IgG Results:
Band 34 IND (Indeterminate)
Band 39 IND
Band 41 ++
Band 58 ++

WB IgM Results:
Band 31 IND
Band 34 +
Band 39 IND
Band 41 ++
Band 66 +

Also, appears B Duncani Antibody Panel - Babesia IgM positive (Titer 1:40), HME Panel - Ehrlichiosis IgM positive (Titer 1:20), B. Henselae Antibody G/M - Bartonella IgM positive (Titer 1:40). IgG's were negative on all of these.

I will discuss all of this with my doc tomorrow AM....since I am in WA State, Lyme is much less common. She has treated 15-20 patients and I really like her and have confidence in her. I just also want to draw on all of your experience as well and want to make good decisions regarding treatment. Again, appreciate your guess is at this point, I do have a Lyme diagnosis...don't you think? Wishing good/better health for you all. Mona
Hi Mona. I am sorry you have Lyme and three co-infecitons, but it is good to know so you can start treatment. Many Lyme doctors believe the co-infections need to be treated first for Lyme treatment to be effective. This was true in my case.

Below is the breakdown of the Western Blot bands:

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

The IgM tests for a more recent infection, the IgG a longer standing one. Band 41 is often the first to show, and yours are positive. Bands 31, 34, and 39 are Lyme specific bands and yours are either positive or IND. I believe these results are significant.

The CDC requires several bands to show for the test to be positive; however, many people who have Lyme do not have this many bands. Lyme doctors often look at which bands are positive--some are specific for Lyme.

Let us know what treatment you will be starting. Good luck!

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