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I've been on 400mg a day of plaquenil for about two weeks now, along with 400mg a day of Doxycycline.... Suddenly I feel like a bag of human excrement. my whole body is sore, and I have a nasty headache. My joints are snapping a lot, too. Does this sound like a herx reaction, or are the drugs just not working?
I believe you are having a herx. I had something similiar. Came on out of no where but it felt like my body weighed a ton just to move my leg and I am a small person. Several members here said it sounded like a herx so at least I know it was worth it.

Hope you feel better soon.





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