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Lyme Disease Message Board


Lyme Disease Board Index


Re: Lyme
Jun 12, 2008
Hi Vickyl, It appears that you are positive for IgG (Long Standing Infection). You have no positive bands on the IgM (short term infection). However IgG can be read as an indication of a current infection, or of past exposure to or past infection by the organism. You are missing one band on the IgG to be declared a Lymie by CDC standard's. The CDC requires at least two band's on the IgM to be declared a Lymie, and you have zero. Do you have symptoms? If you have symptoms then you need treatment. Most LLMD's treat Lyme as a clinical diagnosis. Because the blood tests are so inaccurate. IND means not enough antibody's showed up on that band, however something showed up. Most LLMD's read IND as positive. Here is a breakdown of the bands. Hope it helps:


Igenex Western Blot Break Down by band

9 cross-reactive for Borrellia

12 specific for Bb

18 highly specific to Lyme (Many LLMD's say if this band alone is positive, you have lyme - see link above)

20 cross-reactive for Borrellia

21 unknown

22 specific for Bb, probably really the 23/25 band

23-25 outer surface protein C (OspC), specific for Bb

28 unknown

30 unknown; probably an outer surface protein; common in European and

one California strain - Has cross-reactivity with several different types of viruses

31 outer surface protein A (OspA), specific for Bb - Has cross-reactivity with several different types of viruses

34 outer surface protein B (Osp; specific for Bb

35 specific for Bb

37 specific for Bb

38 cross-reactive for Bb

39 is a major protein of Bb flagellin; specific for Bb

41 flagellin protein of all spirochetes; this is usually the first to appear after a spirochete infection but is NOT specific to Lyme (i.e, other spirochete diseases have flagellas)

45 cross-reactive for all Borellia

50 cross-reactive for all Borrellia

55 cross-reactive for all Borrellia

57 cross-reactive for all Borrellia

58 unknown but may be a heat-shock Bb protein

60 cross reactive for all Borrellia

66 cross-reactive for all Borrelia, common in all bacteria

83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane

93 unknown, probably the same protein in band 83, just migrates differently in some patients[/b]


An IgM positive test result means more recent & likely currently active infection. IgG positive means previous exposure to the bacteria or older infection of Lyme. If no symptoms are present with IgG positive, it may mean an "inactive" LD infection. Whatever the results, please remember LD is a clinical diagnosis, you can have a negative test and still have Lyme Disease and the co-infections.
Re: Lyme
Jun 13, 2008
Thanks, could you tell me what a band is. Is the the * or the + . What shows the bands?

Thanks for you advice I appreciate it very much.

Vicky


[QUOTE=KSA84;3606953]Hi Vickyl, It appears that you are positive for IgG (Long Standing Infection). You have no positive bands on the IgM (short term infection). However IgG can be read as an indication of a current infection, or of past exposure to or past infection by the organism. You are missing one band on the IgG to be declared a Lymie by CDC standard's. The CDC requires at least two band's on the IgM to be declared a Lymie, and you have zero. Do you have symptoms? If you have symptoms then you need treatment. Most LLMD's treat Lyme as a clinical diagnosis. Because the blood tests are so inaccurate. IND means not enough antibody's showed up on that band, however something showed up. Most LLMD's read IND as positive. Here is a breakdown of the bands. Hope it helps:


Igenex Western Blot Break Down by band

9 cross-reactive for Borrellia

12 specific for Bb

18 highly specific to Lyme (Many LLMD's say if this band alone is positive, you have lyme - see link above)

20 cross-reactive for Borrellia

21 unknown

22 specific for Bb, probably really the 23/25 band

23-25 outer surface protein C (OspC), specific for Bb

28 unknown

30 unknown; probably an outer surface protein; common in European and

one California strain - Has cross-reactivity with several different types of viruses

31 outer surface protein A (OspA), specific for Bb - Has cross-reactivity with several different types of viruses

34 outer surface protein B (Osp; specific for Bb

35 specific for Bb

37 specific for Bb

38 cross-reactive for Bb

39 is a major protein of Bb flagellin; specific for Bb

41 flagellin protein of all spirochetes; this is usually the first to appear after a spirochete infection but is NOT specific to Lyme (i.e, other spirochete diseases have flagellas)

45 cross-reactive for all Borellia

50 cross-reactive for all Borrellia

55 cross-reactive for all Borrellia

57 cross-reactive for all Borrellia

58 unknown but may be a heat-shock Bb protein

60 cross reactive for all Borrellia

66 cross-reactive for all Borrelia, common in all bacteria

83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane

93 unknown, probably the same protein in band 83, just migrates differently in some patients[/b]


An IgM positive test result means more recent & likely currently active infection. IgG positive means previous exposure to the bacteria or older infection of Lyme. If no symptoms are present with IgG positive, it may mean an "inactive" LD infection. Whatever the results, please remember LD is a clinical diagnosis, you can have a negative test and still have Lyme Disease and the co-infections.[/QUOTE]





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