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His test read:
LYME DISEASE AB (IGG), BLOT (POSITIVE)
LYME DISEASE AB (IGM), BLOT (NEGATIVE)

Five reactive bands were listed under the IGG, BLOT (18, 39, 42, 58,& 93)
One reactive band was listed under IGM, BLOT (41)

My confusion came from the IGG being positive and the IGM being negative. Can you shed some light on this finding??
[QUOTE=unsureinfl;5329718]His test read:
LYME DISEASE AB (IGG), BLOT (POSITIVE)
LYME DISEASE AB (IGM), BLOT (NEGATIVE)

Five reactive bands were listed under the IGG, BLOT (18, 39, 42, 58,& 93)
One reactive band was listed under IGM, BLOT (41)

My confusion came from the IGG being positive and the IGM being negative. Can you shed some light on this finding??[/QUOTE]

[COLOR="RoyalBlue"] Briefly:

IgM is a sign of a current infection.
IgG is a sign of a current infection, or of a past exposure to or past infection.

I really wouldn't get hung up on these results. An LLMD will first look at clinical symptoms. You do have IgG positive. This, along with his clinical symptoms, is a lot more than many legitimate lymies come up with. You don't need to have both IgG and IgM positive for diagnosis. Many diagnoses are made with [I]no[/I] positive test results. The difficulty in accuracy in testing for LD is, unfortunately, the nature of this disease at this point in time.

Tess[/COLOR]
[QUOTE=unsureinfl;5329610]My 15 year old went to the doctor presenting classic mono symptoms; swollen lymph nodes and fatigue.

Monospot test was positive. Additional bloodwork was screened for EBV virus and Lyme. His EBV was positive and his Lyme was positive.

Is there a chance his Lyme test is a false positive?? The tests were screened at Quest Diagnostics. Below are the results of those tests:

EBV 5.0 (high)

PHAGOCYTOPHILUM IGG 1:64 (high)

LYME AB SCREEN 1.90 (high)

LYME DISEASE AB (IGG), BLOT

POSITIVE REACTIVE BANDS:

18 KD, 39 KD, 41 KD, 58 KD, & 93 KD

LYME DISEASE AB (IGM), BLOT

POSITIVE RRACTIVE BAND:

41 KD

My questions:

Does he have Lyme, EBV or both??

Could the Lyme test be a false positive because of current EBV infection?

Or, Could the EBV be a false positive because of Lyme?

I'm really confused and concerned. Any help would be much appreciated. Thanks in advance![/QUOTE]


12/22/2014 An update on lab results from IGenex:
The lab results from IGenex just add to my confusion! The lab results seen above are from Quest Labs and these are IGenex:

IGENEX-IgG-RESULT: POSITIVE
CDC/NYS-RESULT: NEGATIVE
39 kDa +
41 kDa ++

IGENEX-IgM-RESULT: POSITIVE
CDC/NYS-RESULT: POSITIVE
31 kDa +
39 kDa ++
41 kDa ++++
83-93 kDa IND

A. Phagocytophilum IgM. <20. Negative
A. Phagocytophilum IgG. 160 > or = 160 Indicates active infection

E. chaffeensis IgM <20 Negative
E. Chaffeensis IgG 320 > or = 160 indicates active infection

IFA, B BURGDORFERI G/M/A 40. Equivocal

All other co-infections were NEGATIVE.

As you can see from Quest Labs there were many more "reactive" IGG bands compared to the IGenex results. However, there are several more "reactive" IGM band results from IGenex. I am seeing a LLMD in January and hope to get a better understanding of the lab results.

I'm still confused if my son's active mono is interfering with the test results?? I've read that high titers for EBV can interfere with Western Blot tests, but will only interfere with certain bands and not others. If anyone has any insight on this, I'd like to hear from you.

Thanks in advance for any insight!





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