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Multiple Sclerosis Message Board

Multiple Sclerosis Board Index


Sorry to hear your difficulties. Have you tried stretching and low impact exercises? I know it takes time to get through the spasticity, but it does help. For me, I have cycles of spasticity which increases most often in the colder weather and in the heat of summer. Spring and autumn is best for me.

There has been some work with botox, but with MS, there simply is no guaranteed success. Based on what you have shared, your story can be empathized by many MSers.

As a "whole", stretching and exercise are the most effective in my opinion.

Meds employed for MS to treat spasticity include:
-Baclofen (the most commonly used medication)
-Tizanidine (Zanaflex brand name) works quickly to calm spasms and relax tightened muscles. Although it doesn't produce muscle weakness, it often causes sedation and a dry mouth. In some patients, it may lower blood pressure.

Other alternatives:

-Diazepam (Valium brand name) - it lasts longer than Baclofen, but it can be addictive. Doctors usually have a low dosage prescribed to be taken at bedtime.
-Dantrolene (Dantrium brand name) a "last ditch" med because it can produce serious side effects including liver damage and blood abnormalities.
-Phenol a nerve block agent
-Botulinum toxin (Botox brand name) injections have been shown to be effective in relieving spasticity in individual muscles for up to three months.
-Clonidine (still experimental) Your doctor may be able to arrange this for you.


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