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Elevated CPK Level
Sep 20, 2012
Do your muscles get weaker as your CPK level increases? Mine is only mildly elevated at 271 but has been steadily climbing for the past 18 months. My AST and ALT are also elevated.

Thanks for your input.
Yes, you can get muscle weakness with myositis, and the CK level can be correlated. My myositis seems intermitten, and I can always tell when my CK is up. Mine gets to about the same level as yours, then drops to normal. The AST and ALT can come from muscle as well as liver, so that fits. Do you know what kind of myositis you have? I hope it levels off or drops so it doesn't get worse.
Hi Blessed to be me,
Was wondering how you have been doing. We have some similar issues. Was it ever determined why your ALT and AST were elevated? Mine are more elevated than one year ago...still no answer why. Very frustrating indeed. Hope tohear back from you.
Well, I took 60mg of Prednisone for a couple months, then tapered down. Doc started me on Imuran but after 3 weeks my ALT had climbed to 101 so they put me back on Prednisone and off the Imuran. Seeing a liver specialist next week. Have noticed that the joints in my feet are seriously changing and painful since stopping the Imuran. But what can you do? Liver damage to me is much more serious. Of course, the ALT and AST have gone back down since stopping.

How are you doing? Having muscle weakness?
Well, I took 60mg of Prednisone for a couple months, then tapered down. Doc started me on Imuran but after 3 weeks my ALT had climbed to 101 so they put me back on Prednisone and off the Imuran. Seeing a liver specialist next week. Have noticed that the joints in my feet are seriously changing and painful since stopping the Imuran. But what can you do? Liver damage to me is much more serious. Of course, the ALT and AST have gone back down since stopping.

How are you doing? Having muscle weakness?
The ALT and AST enzymes can come from muscle OR liver tissue. So the lab can "fractionate" the enzymes, meaning separate them into liver vs. muscle to be clear on where the elevation is originating. A GGT is more liver specific, as is bilirubin elevation. If there is truly something going on in the liver, it would make sense to consider autoimmune hepatitis, for which an anti-mitochondrial antibody can be tested on the blood. Given you have some autoimmune problems, that could fit in.
Ladybug, Thank you for your feedback. Last year I did test negative for a hep panel. I'm not sure that the enzymes were fractionized last year or not and GGT doesn't sound familiar so I don't think that was ever done. I'll ask if they were done. I do remember the bilirubins were high along with the ALT and AST though. More things to ask my doc about so I appreciate the information you gave me and I'll follow-up on it. I was tested 2 and 3 years ago for multiple mitochondrial diseases when the neurologist was looking for other reasons for muscle fatigue and pain besides polymyosits. Again, negative..good thing from what I understand.
I know there has to be a reason for the elevated enzymes...and this is going on for more than 2 years now. Where to go from here though. If the ultrasound comes up negative again I feel I'll be forgotten for another year....until the next annual physical. It's frustrating!
Thanks again for your feedback. I appreciate it very much.
That must be why my doc was more concerned with how high the AST was compared to the ALT. I have been having the hepatic function tests every 2 weeks but now that the Imuran is stopped - it is going back to normal. I go tomorrow to see the Rhuemy and the liver specialist. I'm ready to stop the meds totally. I hate how they make me feel. I can say that because my muscles and bones haven't gotten that bad. This may change but I'm kind of hoping it is just a nightmare and sometime I will wake up.

We have even had our 2 story home on the market to sell for the last 2 months to get a single story home and can't find one. I wish I could prove them wrong.





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