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Osteoporosis Message Board

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[QUOTE=Travel]Are you satisfied with only the black box warning? Wouldn't you like to have information beyond that, such as the reason for using the drug for a mandatory limited amount of time? Don't you think you should be fully informed before injecting the drug into your body? Don't you ask yourself WHY they are not giving you more detailed information?

I said in my previous message that if I were having broken bones on a regular basis I might reconsider my decision. It is an individual choice.[/QUOTE]
I'm not trying to be argumentative here, Travel. :D Just making a general philosophical point. I will never be a candidate for Forteo myself. I don't know what information is routinely given by doctors, but I read that a medication guide with more detail must accompany each prescription. I would imagine that is going to be the most up-to-date info. Since you are doing the research (for which I commend you) why not talk to your pharmacist about it?

The Black Box warning goes like this: (I hope it's okay to post this)

In male and female rats, teriparatide caused an increase in the incidence of osteosarcoma (a malignant bone tumor) that was dependent on dose and treatment duration. The effect was observed at systemic exposures to teriparatide ranging from 3 to 60 times the exposure in humans given a 20-mcg dose. Because of the uncertain relevance of the rat osteosarcoma finding to humans, teriparatide should be prescribed only to patients for whom the potential benefits are considered to outweigh the potential risk. Teriparatide should not be prescribed for patients who are at increased baseline risk for osteosarcoma (including those with Paget's disease of bone or unexplained elevations of alkaline phosphatase, open epiphyses, or prior radiation therapy involving the skeleton) ( see WARNINGS and PRECAUTIONS , Carcinogenesis ). [/QUOTE]
Treatment choices can be so tough. I myself just finished 5 years on a drug which has the known side-effects of blood clots and uterine cancer, but which I believe has protected me from the cancer I'm most vulnerable to. I made the decision with my eyes wide open, and with the knowledge that ultimately I (and not my doctors) am responsible for my own health. I wish you and everyone here the best of luck, whatever you should decide! :)
Each Forteo pen comes with three inserts. One of the inserts has the black box warning and tons of information. I've done a lot of research and talked to doctors about this drug. Most of you know about my fractures .... so that played a big part in me deciding to start the injections. Also, it eases my mind (to some extent) that there have been no cases of osteosarcoma in humans who have used Forteo or in primates during and after testing. Rats have a different bone structure than humans. They continue growing throughout their lives unlike humans. Adolescents who are still growing cannot take Forteo because the risk of osteosarcoma would be greater.

I don't know if I would have started Forteo if I had known my bones were so bad but had not had fractures. Now though, I look back (hindsight) and wish I would have had a DEXA scan and started on it before the fractures. It's a tough decision to make because not everyone with weak, brittle bones will suffer a fracture in their 50's or 60's. However, a person is very lucky if they are in the 80-90 age group and haven't had a fracture. The prognosis isn't very good for hip fractures at that age. It's a hard decision to make but I do know that my bone density has improved since starting Forteo. I can actually go shopping and not worry about my feet fracturing. I was starting to get a real phobia about shopping and fractures because they all happened while shopping or right after. Talk about shop till you drop.


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