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Osteoporosis Message Board


Osteoporosis Board Index


Since I recently developed a deep vein thrombosis (blood clot) and am on warfarin (Coumadin) for the next six months I found the following info from an article I read of great interest. Some of you might find the info interesting also.

Bone formation and bone loss involves a complex array of nutrients and molecular signals. This article covers the influence of vitamin K (most specifically K2) on these processes as a separate and distinct requirement from other nutrients. In vitro studies show vitamin K2 is far more active than K1 in both bone formation and reduction of bone loss. Human studies demonstrate the potential of vitamin K2 as a strategic intervention for osteoporosis. This treatment is already in general use outside the United States, at a typical dose of 45 mg daily.

Studies confirm the effectiveness of vitamin K2 for decreased BMD from a variety of causes, including postmenopausal osteoporosis, Parkinson's disease, use of leuprolide or prednisolone, biliary cirrhosis, stroke inactivity, and anorexia. Few, if any, multiple vitamin and mineral supplements contain vitamin K2. The authors recommend it be more widely supplemented as it has beneficial activity far beyond osteoporosis. Supplementation becomes even more important for those with a tendency to lipid malabsorption. A common
cause of malabsorption is celiac disease, which affects one in 266 persons.

A normal prothrombin time is not an indication that enough vitamin K activity is present to maintain bone osteocalcin activity. Moderately high doses of vitamin K2 do not produce hypercoagulable or toxic states in humans, although the use of K2, like any vitamin K, is contraindicated in people taking warfarin (Coumadin[R]). Considering the extensive application of vitamin K beyond blood coagulation--osteoporosis, anticancer therapy, pain reduction, mitochondrial aspects, hepatitis C, and protection of sphingolipids --the vitamin Ks have been therapeutically underutilized.

All that being said: I do NOT advocate vitamin K supplementation except under the guidance of your doctor. This is just an FYI and if you are interested in trying it you discuss it with your doctor and get his blessing and guidance to do so.





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