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Cancer: Prostate Message Board


Cancer: Prostate Board Index


Free PSA question
Sep 15, 2007
I'm 62 and my PSA spiked at 4.1 three months ago with free PSA of .33, or 8%. Tables said 56% probability of PCa. Uro suggested a biopsy, but I asked for a retest because of symptoms of possible inflammation, along with a negative DRE.

Just had a retest and PSA dropped to 2.6. However, free PSA was .31, or 12%. Tables drop the probability of PCa to 28% but the tables also say they are for PSA values between 4 and 10, and should be considered for research only outside this range.

So I have a PSA velocity going in the right direction, a total value not that bad for my age, but I have this free PSA still too low. Any insight on how meaningful free PSA is for PSAs in the 2s?
[QUOTE=np2202;3209974]I'm 62 and my PSA spiked at 4.1 three months ago with free PSA of .33, or 8%. Tables said 56% probability of PCa. Uro suggested a biopsy, but I asked for a retest because of symptoms of possible inflammation, along with a negative DRE.

Just had a retest and PSA dropped to 2.6. However, free PSA was .31, or 12%. Tables drop the probability of PCa to 28% but the tables also say they are for PSA values between 4 and 10, and should be considered for research only outside this range.

So I have a PSA velocity going in the right direction, a total value not that bad for my age, but I have this free PSA still too low. Any insight on how meaningful free PSA is for PSAs in the 2s?[/QUOTE]

My opinion...

I view the PSA test with a great deal of skepticism. I didn't put a great deal of trust in mine only because there are too many factors that affect the readings. I put a whole lot more faith in a TRUS biopsy. The more core samples the better. I'm no professional, that's just my spin!

Good luck!;)
[QUOTE=np2202;3209974]I'm 62 and my PSA spiked at 4.1 three months ago with free PSA of .33, or 8%. Tables said 56% probability of PCa. Uro suggested a biopsy, but I asked for a retest because of symptoms of possible inflammation, along with a negative DRE.

Just had a retest and PSA dropped to 2.6. However, free PSA was .31, or 12%. Tables drop the probability of PCa to 28% but the tables also say they are for PSA values between 4 and 10, and should be considered for research only outside this range.

So I have a PSA velocity going in the right direction, a total value not that bad for my age, but I have this free PSA still too low. Any insight on how meaningful free PSA is for PSAs in the 2s?[/QUOTE]

I'm going to respond to this original post and your last post (#6 in the thread) separately. I hope you are still subscribed to the thread as there is more you can do that could ease your mind a lot (negative result) or put you on an effective path toward an approach (positive result).

There is a fairly new test available that is much more precise than either the PSA or the free PSA, though it is not conclusive. It is known as PCA3 Plus, and you can find out about it with a web search such as " "prostate cancer" "PCA3 Plus" ". It is a urine test that follows an "attentive" DRE (meaning fairly intensive and lasting a minute, not exactly a "finger wave" ;)).

You could also talk to your doctor about taking the drug finasteride to help eliminate "noise" in the PSA score from BPH, improve the effectiveness of the DRE exam, and also check whether it drops your PSA by 50% or more - a meaningful clue that you do not have prostate cancer. (That's what researchers are concluding; quite a few doctors are not up-to-speed on using finasteride.) (I'm a survivor of nearly 8 years but with no enrolled medical education.)

Jim





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