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Cancer: Prostate Message Board


Cancer: Prostate Board Index


hello, I am new to this bulletin board and would very much appreciate any advice or help anyone could give me regarding my father's current prostate cancer condition. I am very upset at the latest turn in events in the last two months regarding his PSA levels. As I stated they have dramatically increased in the last two months from 0.2 to 8.2. My father was originally diagnosed with prostate cancer about 2 years ago and has been on Lupron (administered every three months) for about 18 months. His PSA level is tested every month and in the beginning of June had his most recent lupron shot. On June 25th he tested at 8.2. In april of that same year he was as low as 0.2...this 0.2 level has remained approximately constant and unchanged for the last 18 months until recently.

My question is that we are getting conflicting advice from his Oncologists and would like to draw on people's experience on this message board who have encountered similar circumstances. We have been seeing one Oncologist to administer the lupron and one Oncologist who is supposedly a foremost authority in prostate cancer.

The oncologist that is administering the lupron is suggesting he discontinue the lupron and PSA tests because it may "jumpstart" the effectiveness again in a couple of months.

The other Oncologist's advice is to stay the course and continue the same regimen because there may be cells that have been rendered dormant by the lupron. These cells, if the lupron is stopped, may become more aggressive

As I stated, anyone that could share any type of advice that has any experience with this would be greatly appreciated

thanks
There is insuffucient information on which to base any comments or thoughts.
What is your father's age? When was he diagnosed? What did his biopsy reveal? i.e. Gleason grade ?; clinical stage?; and what treatment(s) if any has he undergone besides the Lupron? His rapidly increasing PSA while receiving Lupron is of concern but difficult to understand in any context without a more complete picture of his diagnosis, clinical background and status.
[QUOTE=shs50;3685335]There is insuffucient information on which to base any comments or thoughts.
What is your father's age? When was he diagnosed? What did his biopsy reveal? i.e. Gleason grade ?; clinical stage?; and what treatment(s) if any has he undergone besides the Lupron? His rapidly increasing PSA while receiving Lupron is of concern but difficult to understand in any context without a more complete picture of his diagnosis, clinical background and status.[/QUOTE]


Sorry for the incomplete information...I'm new at this. My father is 75 and he was diagnosed 2 years ago. He has a 9 on the gleason scale. According to his doctors there are "hotspots" in his back and a few joints that they have presumed may be cancerous. He has only undergone the lupron treatment thus far and is extremely reluctant to do anything much more invasive. I am grateful for any responses and am very interested in finding out more about both intermittent vs. continuous lupron treatment and if he may want to try anything in addition to lupron.

thanks again
My limited and non-professional understanding is that in a case of aggressive prostate cancer, Gleason Grade 9, which has metastasized to the bones as your father's evidently has, there is no invasive treatment to be performed. Treatments at this stage are largely "palliative" ,that is aimed at retarding the progress of the disease, i.e.lupron, until the cancer becomes "hormone refractory" and then controlling its affects and pain. Medication can be given to minimize bone destruction and avoid fractures ,the biphosphonates e.g. Aredia,,Bonefos, Zometa. Strontium 89, a radioisotope can be given to curtail and prevent bone metatstases. Pain medication can be given beginning with Nsaids and eventully morphine if the pain becomes severe. Your father's oncologist should be able to advise and prescribe these drugs and second opinions sought if you don't feel his primary oncologist is doing all that can or should be done to keep your father comfortable while at the same time retarding the progress of his cancer with the most advanced drugs and methods available.





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