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Cancer: Prostate Message Board

Cancer: Prostate Board Index


I wonder why you are so focus in the Finasteride effectiveness or its study indicating 50% lower reading factor. Any direction that Finasteride could take would not alter the positive conclusion of the increased PSA from your last test.
This increase is of concern and so it is the comment regarding prostate cancer in your family history. After Cipro a normal DRE and a proven PSA double increase in 10 months, the diagnosis is very indicative of the presence of cancer. This fact can be ruled out only with a biopsy.
Biopsy is an easy procedure done with localized anaesthesia on an out-patient basis. Surely it should be done in reliable institutions to avoid any infection.

I would suggest you to get a second opinion on your case the sonnest.

Wishing you peace of mind.
Welcome to the board.
Baptista ;)

You have all the reasons to be optimistic. Your PSA is not that high, and you have not been diagnosed with cancer yet. You need to find firstly the cause of that steady increase of PSA.
Many causes other than cancer may influence variations in the PSA. Prostate trauma, passing hard stool or sex the night before drawing blood or riding a bicycle, any infection or inflammation can affect variations in the PSA.
Even if you were diagnosed with PC, there are a series of successful newer ways of treatment to handle the problem, as well as did your father. Be optimistic.

Finasteride is used to treat benign prostate hyperplasia (BPH) which is an inflammation of the prostate (an enlargement of its volume). I never read that it has been ineffective in some cases, but who knows. Nevertheless, in your case doctors have found non palpable enlargement (negative DRE) and if there were some sort of enlargement at the beginning when you had urination symptoms, the drug would have worked on it shirking the prostate and stopping any PSA variation.

The worrisome is on your family history. Your father has been diagnosed with an “aggressive form” of cancer (your above post) and that places you on a high risk (4 times) probability to have cancer. Any increase on PSA should be taken serious but not in panic. Not all males in the same family get cancer.

I have been diagnosed with prostate cancer when on my 50 years old. DRE was negative but the PSA was very high (22.4). There are many cases of cancer in guys in their 40th with PSA in the levels of 2.5.
I would suggest you to read about the protocols of biopsies and if your doctor sees it proper, to have one for peace of mind. Just like a preventive PSA, biopsies and image studies are recommended in cases similar to yours.

Wishing you the best.
Baptista ;)
[COLOR="DarkGreen"]Hi Willies,

Welcome to the board, though hopefully you will not become a full member. ;)

Baptista has already covered important points, but I hope this will catch you in time to reconsider getting a biopsy now. It may be the best course, but the decision deserves some more information and thought. I'll add some thoughts in green using your post #3 as the base:

First I am reconstructing your information as follows. Is it correct?

-mid-February 2010: See GP for frequent urination:
normal DRE, prescribed Cipro and finasteride.

-late July 2010: See uro as frequent urination continuing. First PSA 1.8 after five to six months of finasteride; DRE normal. (There was no October consultation based on your detailed review of the record.)

-mid-May 2011 See uro: PSA 1.3; thorough DRE “normal, advised to get another PSA in six months.

[QUOTE=TheWillies;4760263]Hi Baptista. Thanks for your assessment. I had to go back and look at my medical records this morning and discovered that ...That first test was 1.08 (actual number from the result page). The second test 10 months later was 1.29, so approximately a 20% increase. (if you factor in the Finasteride at 50%, then the actual numbers are closer to 2.2 on the first test and 2.6 on the second).

Even with that, I am concerned enough to go back to the Uro and request a biopsy.[/QUOTE]

[COLOR="darkgreen"]Your current decision is reasonable, but it may not be the best course, and your uro's plan is also reasonable. A point toward going ahead now is that increasing PSA after finasteride has cleaned up the picture by reducing "noise" in the PSA signal from any BPH. Finasteride appears also to eliminate low-grade prostate cancer - the kind that is almost always not lethal, thereby eliminating another kind of noise.

On the other hand, there can be substantial day-to-day variation in PSA, and it could also well be that a subtle infection is still driving part or all of the elevation. A short course or even a longer course of just one antibiotic like Cipro is frequently not sufficient to eliminate an infection or inflammation of the prostate. Are you still experiencing frequency of urination, which is often a signal for continuing infection?

So what's the cost of doing a biopsy now? The best source I know on this is an outstanding recent book (August 2010) entitled "Invasion of the Prostate Snatchers - No More [I][U]Unnecessary[/U][/I] Biopsies, Radical Treatment or Loss of Sexual Potency," (my Italics and underlining) by Ralph H. Blum (the doctor's patient) and Mark Scholz, MD, an expert medical oncologist whose practice is dedicated to prostate cancer. Chapter 8, pages 79-86, is entitled "To Biopsy or Not to Biopsy: Opening Pandora's Box." Here are some sentences that explain the chapter title: "Very few men understand what they are getting into when a biopsy is recommended. Family doctors and urologists schedule biopsies at the first sign of an elevated PSA, rarely educating their patients about what is likely to follow. Once a diagnosis of cancer is made, irrational fears drive most men into immediate radical therapy, even though [I]Low-Risk[/I] [author's emphasis] prostate cancer is not life threatening. Having a biopsy can be like opening Pandora's box."

The chapter goes on to discuss how biopsies often lead to overtreatment, a widely acknowledged fact, several rare but real risks of biopsies, substantial but limited effectiveness of biopsies (fail to pick up cancer 20% of the time while succeeding 80% of the time), insurance considerations (pre-existing conditions, a concern that will be erased for many by the new health reform law), BPH and its influence on PSA and biopsy decisions, PSA density, PSA velocity, other causes for a PSA increase, the role of the DRE, PCA-3 tests (more about this below), and two approaches the doctor does not care for ("free PSA" testing - because it is thrown off by infections, which often produce low scores (meaning less than 10%), and age-based PSA standards, because there is too much variation among men in each age range).

The doctor recommends simply repeating the PSA test as a first step; that can smoke out day-to-day variation. He follows that with a standard recommendation to try to discover and eliminate any infection. If those don't eliminate the concern, he suggests doing a PCA-3 test, a color Doppler ultrasound of the prostate (done by one of the few experts with special CDU equipment; reveals vascularity - new blood vessel formation, which is associated with cancer), or a spectrographic endorectal MRI. Among other clues, this will establish prostate size, permitting calculation of PSA density. (A version of the PCA-3 test, PCA3Plus, is analyzed by the highly respected pathology company Bostwick Laboratories in Richmond, VA.) Doctor Scholz summarizes as follows: "If the PCA-3 and PSA density are favorable, and if imaging fails to reveal any worrisome lesions, active surveillance with frequent PSA and PCA-3 testing, along with periodic imaging, may be preferable to an immediate biopsy." Of course, if the doctor is able to find the appropriate antibiotic for an infection, that may drive the PSA downward and resolve the issue.

One of the concerns the doctor mentions is risk of infection that will require hospitalization. This is still considered rare, but a recent research paper indicated it is a growing concern, a concern mentioned by experts, especially for patients who may have been exposed to bacteria that are resistant to antibiotics. While the biopsy itself would be very unlikely to directly cause such an infection, the biopsy needle may open the door to a harbored infection as it transits through the rectum. The bottom line here is that biopsies are very important and well-worth the rare risks they entail, provided they are employed in a sound manner.

I'm impressed that your urologist is actually looking for another PSA data point at this time rather than rushing to a biopsy; that's a good sign that he is keeping up with research and sound practice. Here's what I would do as I try to see the world from your viewpoint: have a repeat PSA now, and perhaps again in three months, and have a PCA3Plus test done (requires an "attentive" - meaning fairly vigorous, minute long prostate massage, which causes some prostate cells to be shed into urine, which is then collected and analyzed). [/COLOR]

[QUOTE]Given my family history, it's entirely possibly that it's only a matter of time before I am diagnosed with prostate cancer, so I may as well get it over with sooner than later, especially when the prognosis will be potentially better. [/QUOTE]

[COLOR="darkgreen"]That sure is not the way I would look at it! First, [I][U]genes are not destiny[/U][/I], and we already know a lot about how lifestyle tactics, such as diet, exercise and stress reduction, appear to influence prostate cancer. The "epigenetic" environment that determines whether genes are turned on or not is very important. Second, while some men are very fortunate in being able to have curative therapy with minimal impact on their lives, the vast majority is not so fortunate. Curative prostate therapy is [U]not like an appendectomy[/U] where you can get it done and over quickly without a long tail of side effects. Therapy is worth the burden when the risk posed by the cancer is major; often it is not major, something that was not realized as recently as eight years ago when the first success for "active surveillance" began to be published.

Also, if you have cancer and it is appropriately assessed and monitored, your prognosis should be virtually as good even if treatment is deferred. That is the sound and appealing approach known as "active surveillance", an approach whose effectiveness has been well documented during the past ten years. Meanwhile, while treatment - if it is ever necessary - is deferred, your outcome should be much better due to the constant pace of substantial improvement in prostate cancer technology. One option - surgery - is often considered inadvisable once a patient turns 70, but you are a long way from age 70, and surgery is far from the only option, and is arguably not the best option for many patients.[/COLOR]

[QUOTE]I was focused on the effect of the Finasteride more from a wishful thinking perspective, that not everyone responds in such a predictable way to it and that perhaps it was not having as much of an effect on me as it did on others that were part of the study. Maybe too analytical and optimistic ...

All The Best.[/QUOTE]

[COLOR="darkgreen"]That course of finasteride is likely preventing any low-grade prostate cancer, and it has provided you with a clearer signal, triggering legitimate concern. Just don't get spooked. Try to find out the rest of what is going on.

Take care and hang in there,

Jim :wave:[/COLOR]

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